CHESHIRE: EHE Implementation Science Hubs
CHESHIRE: EHE Implementation Science Hubs
A Novel Approach to Improving Implementation Science Capacity
Since 2019, the National Institutes of Health (NIH) have funded 260 projects through the Ending the HIV Epidemic in the United States (EHE) initiative with the aim of identifying best practices for delivering evidence-based HIV interventions. To coordinate EHE projects and accelerate implementation research and findings, NIH funded the HIV Implementation Science Coordination Initiative (ISCI), a national coordinating center, as well as eight regional consultation Implementation Science Hubs.
As ISCI and the Implementation Science Hubs have collaboratively piloted and refined ways to support projects, they have become known as the Capacity-building Hubs to Enhance the Science of HIV Implementation REsearch (CHESHIRE) network. Through its unique capacity-building model, the CHESHIRE network supports rigorous implementation science by providing projects with support services such as technical assistance and cross-project information sharing, measure harmonization, and data synthesis. The CHESHIRE network model is a novel, system-wide approach for rapidly improving implementation science capacity.
To learn more about the first five years of CHESHIRE, read the 2025 JAIDS Supplemental Issue article, “Building the Road to End the HIV Epidemic Through Coordinating and Capacity-Building Hubs to Enhance the Science of HIV Implementation REsearch (CHESHIRE): Reflections and Directions.”

Since 2019, the National Institutes of Health (NIH) have funded 260 projects through the Ending the HIV Epidemic in the United States (EHE) initiative with the aim of identifying best practices for delivering evidence-based HIV interventions. To coordinate EHE projects and accelerate implementation research and findings, NIH funded the HIV Implementation Science Coordination Initiative (ISCI), a national coordinating center, as well as eight regional consultation Implementation Science Hubs.
As ISCI and the Implementation Science Hubs have collaboratively piloted and refined ways to support projects, they have become known as the Capacity-building Hubs to Enhance the Science of HIV Implementation REsearch (CHESHIRE) network. Through its unique capacity-building model, the CHESHIRE network supports rigorous implementation science by providing projects with support services such as technical assistance and cross-project information sharing, measure harmonization, and data synthesis. The CHESHIRE network model is a novel, system-wide approach for rapidly improving implementation science capacity.
To learn more about the first five years of CHESHIRE, read the 2025 JAIDS Supplemental Issue article, “Building the Road to End the HIV Epidemic Through Coordinating and Capacity-Building Hubs to Enhance the Science of HIV Implementation REsearch (CHESHIRE): Reflections and Directions.”
Map of the CHESHIRE Hubs
Coordination and Consultation Hub Support Services and Activities
The CHESHIRE Hubs provide implementation science consultation and support to funded research projects and grant proposals with a focus on HIV research in the United States. Read below to learn more about CHESHIRE Hub support services and click on the button to fill out the intake form. Your project/proposal will then be matched with an Implementation Science Regional Consultation Hub based on expertise and capacity.
ISCI Coordination Hub
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- Conducts data collection and harmonization across EHE-funded projects
- Facilitates knowledge sharing of methods, study findings, and trainings through an online HIV implementation science repository
- Creates and disseminates generalizable knowledge to accelerate the translation from research to practice
Implementation Science Consultation Hubs
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- Oversee portfolios of related projects
- Offer tailored coaching, broader implementation science technical assistance, and cross-project learning
- Facilitate and assist projects with mandatory reporting of NIH required measures and outcomes to ISCI
- Contribute to generalizable knowledge activities
More About Implementation Science Consultation Hubs
- Johns Hopkins HIV Implementation Science Hub
- San Diego Implementation Science Hub
- Southeast HIV Implementation Science Hub
- Texas Implementation Science Research Consultation Hub to End HIV
- University of Alabama at Birmingham Regional Consultation Hub for Precision HIV Implementation Science
- UCLA Rapid, Rigorous, Relevant Implementation Science Hub
- University of Washington Research Alliance in Implementation Science to End HIV (RAISE) Hub
- Yale Rigorous, Rapid, & Relevant Evidence aDaptation to EHE (R3EDI) Hub
Johns Hopkins HIV Implementation Science Hub
Principal Investigators: Sheree Schwartz, PhD, MPH; Stefan Baral, MD, MPH, MBA, MSc
The Hopkins Hub provides technical assistance through coaching, group-based mentorship, training, and review to Center for AIDS Research (CFAR) investigators, EHE awardees, health department officials, community stakeholders, and other HIV implementation science investigators. The Hub, funded by the NIH under the national EHE initiative, seeks to accelerate HIV prevention, diagnosis, and treatment strategies by providing mentoring and technical support to ongoing and future implementation science projects and investigators.
The Hopkins Hub also offers mentorship and development opportunities through didactic training, applied learning activities, and intensive implementation science coaching. By expanding collaboration and strengthening partnerships with Health Departments and community stakeholders, the Hopkins Hub is developing a collaborative network aimed at supporting the EHE agenda and NIH HIV/AIDS research priorities.
San Diego Implementation Science Hub
Principal Investigators: Borsika Rabin, PhD, MPH, PharmD; Nicole Stadnick, PhD, MPH; Laramie Smith, PhD
The San Diego Implementation Science (SD IS) Hub advances HIV implementation science by providing precision implementation science coaching, bi-directional capacity building, innovative dissemination support, and population-impact–focused evaluation to HIV research teams across the United States. Building on four years of successful Hub operations and strong institutional partnerships between the Dissemination & Implementation Science Center and the San Diego Center for AIDS Research, the SD IS Hub expands its services to meet the evolving needs of R-level HIV projects—including advanced methodological expertise, implementer-centered learning opportunities, and tailored dissemination products that strengthen relevance, feasibility, and community benefit. Through collaborative coaching teams, a new Implementer Learning Core, a dedicated Dissemination Core, and an enhanced evaluation structure centered on Translational Science Benefits (TSB), the SD IS Hub is positioned to accelerate high-impact, community-engaged HIV implementation research and support the sustained translation of HIV innovations into practice.
San Diego Implementation Science Hub Website
Southeast HIV Implementation Science Hub
Principal Investigators: Carolyn Audet, PhD; Jessica Sales, PhD
Emory and Vanderbilt have partnered to create the Southeast HIV Implementation Science Hub (SEIS Hub). The overarching goal of the SEIS Hub is to improve health outcomes by elevating the quality of implementation science within HIV research, build capacity of researcher and community/clinic partners, and ensure strong “hand off” dissemination plans are established before the conclusion of any successful project. SEIS has assembled an outstanding team to (1) support the entire academic-community/implementing partner EHE grantee team’s needs, (2) support capacity-building around dissemination and transition planning, and (3) collaborate with the CHESHIRE network to advance HIV implementation science and progress towards EHE goals.
SEIS Hub Listserv Sign-Up Form
Texas Implementation Science Research Consultation Hub to End HIV
Principal Investigators: Serena A. Rodriguez, PhD, MS, MPH (contact PI); Bijal A. Balasubramanian, MBBS, PhD; Christine M. Markham, PhD
The Texas Implementation Science Research Consultation Hub (TX IS Hub) is a federally funded initiative designed to accelerate the translation of evidence-based HIV prevention, treatment, and care strategies into practice across Texas and the Southern U.S. With five Ending the HIV Epidemic priority jurisdictions located in Texas, the Hub provides a critical infrastructure to address persistent disparities, limited Medicaid expansion, and gaps in implementation capacity. The Hub synthesizes implementation science knowledge, disseminates tools and resources, delivers coaching and technical assistance to researchers and community organizations, and builds capacity through training, consultation, and cross-institutional collaboration. By partnering with regional and national networks, the Hub strengthens implementation research, practice, and policy efforts to advance progress toward ending the HIV epidemic.
TX IS Hub Listserv Sign-Up Form
University of Alabama at Birmingham Regional Consultation Hub for Precision HIV Implementation Science
Principal Investigators: Renee Heffron, PhD, MPH; Robin Lanzi, PhD, MPH
The University of Alabama at Birmingham (UAB) Regional Consultation Hub for Precision HIV Implementation Science (IS) serves as a national and regional resource to advance efforts to end the HIV epidemic through precision-aligned, community-engaged, policy-relevant approaches and strategic partnerships. Located in Alabama, one of the states emphasized in the US Ending the Epidemic (EHE) initiative, the Hub features a multidisciplinary team of scientists with expertise in implementation science, academic-public health department partnerships, HIV clinical and public health practice, health policy, community-engaged science, social determinants of health (SDOH), and the HIV epidemic in the US South.
The Hub provides flexible, tailored support through consultations, technical advising and coaching, capacity-building programs, and access to monthly drop-in “conversation hours,” supporting investigators from conceptualization through implementation and dissemination. The Hub’s training efforts span the research pipeline, from high school and undergraduate learners to early- and mid-career HIV implementation scientists, expanding capacity in the field.
UAB Regional Consultation Hub for Precision HIV IS Website
UCLA Rapid, Rigorous, Relevant Implementation Science Hub
Principal Investigator: Alison Hamilton, PhD, MPH
The UCLA Rapid, Rigorous, Relevant Implementation Science Hub (3R IS Hub) provides leadership and support for HIV-related implementation research emphasizing pragmatic study designs and methods that address health disparities and produce sustainable solutions. The Hub is supported by an Ending the HIV Epidemic (EHE) supplement award from the National Institute of Mental Health. EHE awardees assigned to the UCLA 3R IS Hub will have access to individualized consultation, coaching, and technical assistance sessions; timely roundtable feedback; IS methods workshops; expert discussion sessions; and lectures and resources that will advance the application of IS concepts, theories, frameworks, and methods.
University of Washington Research Alliance in Implementation Science to End HIV (RAISE) Hub
Principal Investigator: Kenneth Sherr, PhD, MPH
Launched in August 2022, the Research Alliance in Implementation Science to End HIV (RAISE) Hub aims to advance the contribution of implementation science towards the Ending the HIV Epidemic (EHE) initiative in the United States. RAISE is led by Kenneth Sherr in close collaboration with Matthew Golden, Christine Khosropour, Arianna Means, and a distinguished group of expert faculty. RAISE provides implementation science consultation to NIH-funded EHE research projects designed to improve the uptake and effectiveness of HIV/AIDS interventions and bend the curve on the HIV epidemic in the United States. RAISE also works in partnership with the National Alliance of State and Territorial AIDS Directors (NASTAD) to provide technical assistance in implementation research to health departments in EHE jurisdictions.
UW RAISE Hub Website
Yale Rigorous, Rapid, & Relevant Evidence aDaptation to EHE (R3EDI) Hub
Principal Investigators: Debbie Humphries, PhD, MPH, MA; Luke Davis, MD
The focus of the Yale R3EDI Hub is on 1) advanced quantitative and qualitative Implementation Science methods, and 2) community-engaged research (CEnR), two areas that build on expertise at Yale CMIPS and Yale CIRA. Based on needs identified through prior EHE support, the R3EDI Hub has assembled an exceptional team to provide technical assistance and technical resources in the above areas, including: Community-Based Participatory Research (CBPR) Accelerator; Implementing Partners Community of Practice (CoP); Social Determinants of Health database covering all 57 EHE jurisdictions; Community-facing Dissemination Templates; Multi-Site Research within the CHESHIRE Network; and an HIV Visiting Scholars Program.
R3EDI Website
CHESHIRE Events and Meetings
Taking Stock of HIV Implementation Research: EHE Findings and CHESHIRE Network Services
On December 18, 2025, CHESHIRE and NIH co-organized the hybrid seminar, “Taking Stock of HIV Implementation Research: EHE Findings and CHESHIRE Network Services.” The seminar examined the incredible progress made through the EHE initiative since its inception in 2019. Presentations featured CHESHIRE research and services from ISCI and the eight Implementation Science Hubs. The livestream was open to the public, while the in-person portion of the seminar was limited to CHESHIRE members and federal agency staff. After the livestream ended, in-person attendees participated in a facilitated discussion and informal networking lunch.
The in-person component of the seminar was hosted at the National Institute of Allergy and Infectious Diseases (NIAID) in Rockville, MD. View the agenda for more information. To learn more about the December 2025 CHESHIRE seminar, view the PowerPoint presentations:
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- Seminar Kickoff – Dennis H. Li, PhD, MPH; ISCI
- Overview of the Initiative to End the HIV Epidemic in the United States – Geri R. Donenberg, PhD; National Institutes of Health, Office of AIDS Research
- EHE Findings, Accomplishments, and Progress Since 2019 – Brian Mustanski, PhD; Nanette Benbow, MA; ISCI
- Implementation Science Hubs’ Core Services and Activities – Implementation Science Hub Directors (view the agenda for the list of Hubs and presenters)
- Evaluation of the CHESHIRE Network – Debbie Humphries, PhD, MPH, MA; Rigorous, Rapid, & Relevant Evidence aDaptation to EHE (R3EDI) Hub
- Multisite Study of Rapid Start – Sheree Schwartz, PhD, MPH; Johns Hopkins HIV Implementation Science Hub